83-5973-35　Respiratory Syncytial Virus (RSV) G Protein 200ug　045758

特徴

• Recombinant monoclonal antibody to RSV G Protein.
• Manufactured using Recombinant Platform with variable regions (i.e.
• specificity) from the hybridoma CB002.5.
• Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants and the elderly.
• The surface of the virion is decorated with the fusion glycoprotein (RSV F) and the attachment glycoprotein (RSV G), which binds to CX3CR1 on human airway epithelial cells to mediate viral attachment and subsequent infection.
• RSV G is a major target of the humoral immune response, and antibodies that target the central conserved region of G have been shown to neutralize both subtypes of RSV and to protect against severe RSV disease in animal models.
• The binding characterization of this antibody was done using Pepscan-based ELISA.
• This antibody can potently neutralize both subtyes of RSV A2 and B1 in the presence of complement.
• However, it was incapable of neutralizing both subtype in absence of complement.
• The original antibody has 50% inhibitory concentration (IC50) of 0.12 nM and 0.06 nM for strains A2 and B1, respectively.
• This antibody also demonstrated potent neutraliztion of RSV in well-differentiated HBECs cultured at an air-liquid interface, in absence of complement, with an IC50 of 4.7 nM.
• Applications:Suitable for use in ELISA and Neutralization.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.