83-5973-31　Thioredoxin 2 100ul　045753

特徴

• Thioredoxin is a small redox protein found in many eukaryotes and prokaryotes.
• A pair of cysteines within a highly conserved, active site sequence can be oxidized to form a disulfide bond which is then reduced by thioredoxin reductase.
• Multiple forms of thioredoxin have been identified, including cytosolic thioredoxin 1 (Trx1) and mitochondrial thioredoxin 2 (Trx2).
• Thioredoxin participates in many cellular processes including redox signaling, response to oxidative stress and protein reduction.
• A potential role of thioredoxin in human disorders such as cancer, aging and heart disease is currently under investigation.
• Thioredoxin can play a key role in cancer progression, as it acts as a negative regulator of the proapoptotic kinase ASK1.
• Changes in thioredoxin expression have been associated with meningococcal septic shock and acute lung injury.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.