83-5973-26　ApoE2 100ul　045747

特徴

• Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system.
• Chylomicrons are a fundamental class of apolipoproteins containing very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL).
• Human ApoE has three isoforms: ApoE2, ApoE3, and ApoE4.
• These three isoforms differ in the combination of cysteine and arginine residues located at positions 130 and 176.
• The ApoE2 isoform contains cysteine at both locations.
• ApoE4 has been identified as a genetic risk factor for Alzheimer’s disease (AD), where ApoE2 is neuroprotective, reducing risk of AD by nearly 50%.
• The neuroprotective mechanism of ApoE2 remains under investigation, but studies suggest that this may be due to its overall protein abundance in non-AD human cortex and its unique lipid binding profile compared to ApoE3 and ApoE4, which may increase overall β-amyloid clearance.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000, incubate membrane with diluted primary antibody in 5% BSA, 1X TBS, 0.1% Tween® 20 at 4℃ with gentle shaking, overnight
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.