NS1 proteins are highly conserved structural proteins among the flaviviruses.
Intracellular dimers of the protein facilitate genome replication, whereas the secreted hexameric form plays a role in immunoevasion.
Secreted NS1 has been identified as a potential diagnostic marker for early detection of infections.
In addition to the diagnostic marker, the importance of NS1 has been reported in the development of therapeutics and NS1-based subunit vaccines are at various stages of development (Rastogi, et al., 2016)
Powassan virus is a positive-sense, single-stranded RNA virus that belongs to the genus Flavivirus, of the Flaviviridae family.
POWV is an arbovirus, transmitted by Ixodes and Dermacentor ticks, depending on geography (Hicar et al., 2011).
Infected ticks then transmit the virus to small-medium sized mammals, which act as reservoirs.
POWV can also be transmitted to humans, which are an incidental, dead-end host for the virus (Hermance et al., 2017).
Applications:Suitable for use in ELISA and Immunofluorescence.
Other applications not tested.
Recommended Dilutions:Immunofluorescence: 1:10-1:50ELISA: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1mg
抗体種類：Mab
宿主：mouse
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes the NS1 of Powassan virus. No reactivity with West Nile virus, Eastern Equine Encephalitis virus, Western Equine Encephalitis virus,St. Louis Encephalitis virus and La Crosse virus.
