Recombinant Human Antibody (C2244) is capable of binding to ST2L, expressed in HEK 293 cells.
Expressed as the combination of a heavy chain (HC) containing VH from anti-ST2L mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ST2L proteins mAb and CL of human kappa light chain.
Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family.
IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain.
IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8.
IL1RL1 possibly involved in helper T-cell function.
IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.
Applications:Suitable for use in ELISA and SDS-PAGE.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：human
Grade：Highly Purified
Purity：≥95%
Form：Supplied as a liquid in PBS, pH 7.5.
Specificity：Recognizes Anti IL1RL1/ST2(C2244).
Isotype：IgG
Calc Applications Abbrev：E
Immunogen：Recombinant protein corresponding to humanized IL1RL1/ST2 [Homo sapiens], expressed in CHO cells.
