83-5964-84　CD146, MUC18 (c3.19.1), Research Grade Biosimilar 100ug　591741

特徴

• c3.19.1 refers to a fully human IgG2 monoclonal antibody directed against the MUC18 antigen.
• The antibody was generated using XenoMouse® technology (Abgenix, Inc.
• Fremont, Calif.) and consists of human gamma 2 heavy and kappa light chains with a molecular weight of approximately 150kD.
• CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kD cell adhesion molecule currently used as a marker for endothelial cell lineage.
• As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.
• CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals.
• The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.
• As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
• Applications:Suitable for use in ELISA and SDS-PAGE.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.