Bavituximab is a chimeric anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections.
It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress.
Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Bavituximab anti-cancer is a monoclonal antibody that binds to a basic component of the cell structure called a phospholipid that is exposed only on the surface of tumor blood vessel cells or on cells infected with certain viruses.
Bavituximab binding to the tumor blood vessel cells alerts the body’s immune system to attack the tumor and its blood supply.
This has been shown to inhibit tumor growth and development.
Because in healthy cells the phospholipids are concealed inside the cell, the bavituximab does not bind to them.
This targets the bavituximab to the malignant cells and potentially minimizes unwanted side effects.
Applications:Suitable for use in ELISA and SDS-PAGE.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
