83-5964-10　FcRn, Batoclimab Biosimilar (FCGRT) 1mg　591694

特徴

• Batoclimab (HBM9161) is fully human antibody targeting neonatalFc receptor (FcRn).
• It can accelerate the degradation of autoantibodies in patients with optic neuromyelitis spectrum diseases and other autoimmune diseases.
• FcRn expression is upregulated by pro-inflammatory cytokines (such as TNF-alpha) and prolongs the half-life of IgG and serum albumin by reducing lysosomal degradation in endothelial cells and bone marrow-derived cells.
• Blocking the FcRn-IgG interaction can accelerate the degradation of autoantibodies and mitigate the onset of various pathogenic IgG-mediated autoimmune diseases, including myasthenia gravis, thyroid eye disease, optic neuromyelitis spectrum disease, and immunity Thrombocytopenia.
• Applications:Suitable for use in Functional Assays.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.