83-5963-34　TIGIT Single Domain 100ug　590627

特徴

• The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins.
• It is expressed on several classes of T cells including follicular B helper T cells (TFH).
• TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1).
• Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer.
• Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).
• Applications:Suitable for use in ELISA, Immunofluorescence, Immunocytochemistry, Flow Cytometry and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:ELISA: 0.1ug/mlFlow Cytometry: 1ug/mlImmunocytochemistry: 10ug/mlImmunofluorescence: 20ug/mlImmunohistochemistry (paraffin): 10ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.