83-5962-86　CD54 (ICAM-1, Intercellular Adhesion Molecule 1, Human Rhinovirus Receptor, Precursor, BB2, Major Group Rhinovirus Receptor, P3.58) (Biotin) 100Tests　590557

特徴

• CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily.
• It exhibits a wide tissue distribution being expressed on both hematopoietic and non-hematopoietic cells.
• ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation.
• Expression on endothelium and other non-hematopoietic cells is strongly upregulated by inflammatory mediators.
• The ligands of CD54 are CD11a/LFA-1α and CD11b/Mac-1α.
• Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels particularly in areas of inflammation.
• CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation presumably by enhancing interactions between T cells and APC.
• Applications:Suitable for use in Flow Cytometry, Immunocytochemistry, Neutralization, Immunoprecipitation, ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: frozen sectionsOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20℃.
• Aliquots are stable at -20℃ for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.