MRP1 is a 190kD integral membrane phosphoglycoprotein.
It is a member of the human ATP-binding cassette transporter multidrug resistance protein1 (MRP1), encoded by ABCC1.
MRP1 is expressed in most normal tissues, with higher levels in the testes, lung, skin, small intestine, colon, kidney, placenta, peripheral blood mononuclear cells, and skeletal muscle.
ABCC1 encodes plasma membrane proteins that have important physiological transport functions and mediate a variety of xenobiotics against their concentration gradients.
MRP1 plays an important role in the extrusion of drugs from the cell and their over expression can be a cause of failure of anticancer and antimicrobial chemotherapy.
590550 is reported to be an effective and specific inhibitor of MRP1 activity when used in transport assays with inside-out membrane vesicles.
Applications: Suitable for use in Flow Cytometry.
Other applications have not been tested.
Recommended Dilutions:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes a discontinuous conformation-dependent epitope wholly contained in NBD1 of MRP1 which has been mapped to aa647-932.
Clone # USB：QCRL-3
Isotype：IgG2a,k
Calc Applications Abbrev：FC
Calc Crossreactivity：Hu
Immunogen：Membranes prepared from the human small cell lung cancer cell line, H69AR, which highly over expresses MRP1.
