CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain.
It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates.
The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts.
CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Applications:Suitable for use in Immunohistochemistry and Immunofluorescence..
Other applications not tested.
Recommended Dilution:Immunofluorescence: 0.5-1ug/mlImmunohistochemistry(formalin-fixed paraffin sections): 1-2ug/ml for 30 min at RTOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in 1X PBS, 0.1mg/mL BSA, 0.05% sodium azide.
Specificity：Recognizes human CFTR.
Clone # USB：CFTR/1775R
Isotype：IgG,k
Calc Applications Abbrev：IF IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa258-385 of human CFTR.
