83-5961-40　AIM2 100ug　589936

特徴

• AIM2 is one of the human IFN-inducible proteins, encoding a 39 kD protein.
• It contains a 200 amino acid repeat, which is a signature of the HIN-200 family (hematopoietic IFN-inducible nuclear proteins).
• Expression of AIM2 can inhibit cell growth and tumor formation, possibly through inducing apoptosis and suppressing nuclear factor-κ B transcriptional activity and desensitizing tumor necrosis factor-alpha-mediated nuclear factor-κ B activation.
• Furthermore, the gene for AIM2 shows a high frequency of mutations that are associated with microsatellite unstable colorectal cancers.
• AIM2 plays a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1β and IL-18.
• AIM2 is also essential for mediating inflammatory reactions triggered by cytoplasmic DNA.
• AIM2 is an important sensor for different pathogens through the binding of cytoplasmic double-stranded DNA through HIN-200 domain and formation of inflammatsomes including ASC/AIM2.
• This complex then triggers caspase-1 activation.
• Recent studies also show that AIM2/ASC complex acts as a novel caspase-8 activation platform.
• Applications:Suitable for use in Western Blot and Immunoprecipitation and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.5-2ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.