83-5958-27　CD28 (CD28 Antigen, CD28 Molecule, T cell Antigen CD28, Tp44, T cell Specific Surface Glycoprotein, T cell Specific Surface Glycoprotein CD28) 100ug　171499

特徴

• CD28 is a T-cell surface homodimeric 44kD molecule that belongs to the Ig superfamily (1).
• CD28 is involved in cell adhesion T-B through the binding to its ligand B7/BB1, which is also the ligand for CTLA- 4.
• CD28-B7 interaction is an important cosignal that allows T-cell proliferation and lymphokine production.
• CD28 is associated to a PI3 kinase activity (2).
• The majority of CD4+ T-cells and 50% of CD8+ T-cells express CD28 (3).
• The monoclonal antibody induces T-cell proliferation in costimulation with CD2 monoclonal antibodies (2).
• It also inhibits the CD4+ proliferation in the allogeneic T-cell response (2).
• This antibody has been studied at the Vth International Workshop on Human Leucocyte Differentiation Antigens in Boston (1993).
• Applications:Suitable for use in Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: 1-12ug/mlImmunohistochemistry: frozen sectionsOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.