83-5958-14 ABRA1 (Abraxas 1, CCDC98, FAM175A) 100ug C0005-75A
特徴
- ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex.
- This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability.
- ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1.
- ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
- Applications:Suitable for use in Flow Cytometry, Immunoprecipitation and Western Blot.
- Other applications not tested.
- Recommended Dilution:Western Blot: reducing conditionsFlow Cytometry: 1-2ug/ml.
- Intracellular staining
- Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4℃ for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20℃.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ug
- 抗体種類：Mab
- 宿主：mouse
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by Protein A affinity chromatography.
- Form：Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
- Specificity：Recognizes human ABRA1.
- Clone # USB：ABRA1-01
- Isotype：IgG
- Calc Applications Abbrev：FC IP WB
- Calc Crossreactivity：Hu
- Immunogen：Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
- Swiss Prot Number：Q6UWZ7
- EU Commodity Code：30021010
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