83-5957-78　MICA/MICB (PERB11, MIC, MHC class I chain-related protein A, MICA, MHC class I chain-related protein B, MICB, PERB11.2) (Biotin) 100ug　M3886-75Y2

特徴

• The MIC gene is located in MHC class I region.
• MICA/B are 65-75 kD stress-inducible glycoproteins with highly polymorphic.
• They are MHC class I-like transmembrane molecules that do not associate beta2-microglobulin and do not present peptides.
• MICA and MICB share 85% identify, and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells, fibroblasts, and IFN-alpha-stimulated dendritic cells.
• MIC molecules bind NKG2D, an activating receptor, and induce activation of NK cells, and subset of CD8+ alpha/beta T cells and gamma/delta T cells, as well as suppression of T cell proliferation.
• MICA/B recognition is involved in the regulation of tumor surveillance, viral infection and autoimmune diseases.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilutions:Flow Cytometry: 1ug labels 10e6 cells in 100ulOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20℃.
• Aliquots are stable at -20℃ for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.