CD92, also known as CDW92 and CTL1, is a 70kD choline transporter-like transmembrane protein.
CD92 is important for transport of choline across the membrane for synthesis of cell membrane components and the neurotransmitter, acetylcholine.
CD92 is primarily expressed on monocytes and neutrophils, but can also be found on other myeloid and T-cell subsets.
Ionomycin or calcium ionophore mediates the maturation of monocytic dendritic cells causing down-regulation of CD92 but treatment with IL-10 causes re-expression.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilution:Flow Cytometry: ≤0.5ug/10e6 cells in 100ulOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human CD92. Specific for the C-terminal variant of human CDw92 (isoform 3), also known as CTL1, a 70kDa multipass membrane protein, expressed by monocytes, neutrophils, certain myeloid and T cell lines, and weakly by endothelial cells, fibroblasts and epithelial cells. Reported to augment the LPS induced production of IL10 by monocyte derived dendritic cells (Mo DCs); the reduced expression of CDw92 by MoDCs treated with ionomycin or calcium ionophore, can be reinduced in the presence of IL10 (Wille et al.).
