B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4.
BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells.
Engagement of BTLA by its ligand Herpes Virus Entry Mediator (HVEM) is critical for negatively regulating immune response.
The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells.
BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo.
Tolerant T cells have significant up-regulated expression of BTLA compared with effector and naïve T cells.
BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity.
It has been reported that BTLA may regulate T cell function through binding to B7-H4.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilutions:Flow Cytometry: ≤2ug labels 10e6 cells in 100ulOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human CD272. B5001-60C has agonistic activity on BTLA, resulting in the inhibition of activation.
