CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC)-containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity.
It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs.
This protein also functions as a transporter in the blood-brain barrier.
It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes).
Applications:Suitable for use in Flow Cytometry, Functional Assays (Inhibition), Immunohistochemistry and Immunoprecipitation.
Other applications not tested.
Recommended Dilutions:Flow Cytometry: 1-4ug/mlImmunohistochemistry: frozen and paraffin sections.
Heat mediated antigen retrieval in citrate buffer pH 6.
required for paraffin sections
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4. No preservative added.
Specificity：Recognizes human CD243. Does not react with mouse or rat.
Clone # USB：UIC2
Isotype：IgG2a,k
Calc Applications Abbrev：FC IHC IP
Calc Crossreactivity：Hu
Immunogen：NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
