83-5957-27　Thyroglobulin (Tg, Tgn, AITD 3, AITD3, hTG) 100ug　T5300-17F

特徴

• Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
• Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins.
• The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605kD) found in the thyroid follicular cells.
• It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3.
• Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered.
• Anti hTG is found in all thyroid autoimmune diseases (Hashimoto’s thyroiditis, Graves’s diseases), with the highest level observed in Hashimoto’s thyroiditis.
• Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
• TG is mainly expressed on thyroid follicular cells (99.1%).
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (paraffin sections): 1:80 -1:100; pretreatment: heat retrieval in 0.01M citrate buffer, pH 6.o (microwave oven).
• Positive tissue: thyroid gland, follicular adenoma
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.