TACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, is a 32 kD type III transmembrane protein.
It belongs to TNF receptor superfamily, known as TNFRSF member 13B (TNFRSF13B) or CD267.
TACI is expressed on B cells, and myeloma cells.
TACI contains 2 cysteine-rich domains (CRDs).
Recent studies, however, have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD is removed by alternative splicing.
TACI_d2 contains full affinity for its ligands.
Several proteins (BAFF/BLys, APRIL, Syndecan-2) have been identified as TACI ligands.
The interaction of TACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF-kB and plays a crucial role in humoral immunity by negative regulation of B cell proliferation and survival.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilutions:Flow Cytometry: ≤2ug/10e6 cells in 100ulOptimal dilution to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：rat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human TAC1.
Clone # USB：1A1
Isotype：IgG2a,k
Calc Applications Abbrev：FC
Calc Crossreactivity：Hu
Immunogen：Rat RBL cells transfected with human TACI.
