83-5957-22　STAT1 (Signal Transducer and Activator of Transcription 1, CANDF7, IMD31, ISGF3) 100ug　S7969-05Y

特徴

• STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumor suppression.
• After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA.
• STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers.
• STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation.
• However, the both modifications are important for its maximal transcriptional activity.
• On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.
• Applications:Suitable for use in Western Blot and Immunoprecipitation.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/ml, reducing conditions
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.