83-5956-70　CD31 (PECAM-1, Platelet gpIIa Molecule) (Biotin) 100ug　C2383-01J

特徴

• CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases.
• CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells.
• N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions.
• CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis.
• It is one of key regulatory molecules in vascular system.
• Applications:Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry.
• Other applications have not been tested.
• Recommended Dilutions:Flow Cytometry: 2-4ug/mlImmunohistochemistry: paraffin sectionsOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20℃.
• Aliquots are stable at -20℃ for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.