83-5956-69　CD29 (Integrin beta 1) (Biotin) 100ug　C2381-11

特徴

• CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins.
• These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components.
• This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis.
• Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumor cells during selection in presence of antitumour drug.
• In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation.
• These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease.
• Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
• Applications:
• Suitable for use in Flow Cytometry.
• Other applications have not been tested.
• Recommended Dilutions:Flow Cytometry: 1-2ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20℃.
• Aliquots are stable at -20℃ for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.