The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily.
Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.
This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate.
The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile.
Alternative splicing of this gene results in several products of undetermined function.
Applications:Suitable for use in Immunocytochemistry, Immunohistochemistry and Western Blot.
Other applications have not been tested.
Recommended Dilutions:
Immunocytochemistry: 1:20-1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen sections.
Not suitable for paraffin-embedded tissuesOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Grade：Supernatant
Purity：Supernatant
Form：Supplied as a liquid in 0.7% BSA and 0.09% sodium azide.
Specificity：Recognizes an internal epitope of MDR3 P-glycoprotein. Does not crossreact with human MDR1 P-glycoprotein. Has been reported been to crossreact with mouse MDR2 Pgp (see ref. 1)
Clone # USB：P3II-26
Isotype：IgG2b
Calc Applications Abbrev：IC IHC WB
Immunogen：Fusion protein consisting of a fragment of MDR3 P-gp corresponding to aa629-692.
