83-5956-41　CD123 (IL-3 Receptor alpha Chain, IL-3Ra) 500ug　C2462-04

特徴

• CD123 is a 70 kD alpha chain subunit of the IL-3 receptor (IL-3R alpha).
• It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes.
• This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners.
• CD123 can complex with either the common beta chain (CDw131) or the IL-3R beta chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors.
• CDw131 can complex with the alpha subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R beta subunit is specific for IL-3 but binds with low affinity.
• IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: ≤0.25ug labels 10e6 cells in 100ul
• Optimal dilution determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.