MMAE （monomethyl auristatin E） is an antimitotic agent that binds tubulin and inhibits the assembly of microtubules.
Mc-VC-PAB-MMAE is a thiol reactive derivative of MMAE that contains a cathepsin cleavable valine-citrulline p-aminobenzylcarbamate linkage.
Mc-VC-PAB-MMAE is used to prepare antibody-drug conjugates, such as brentuximab vedotin （Seattle Genetics）.
This HRP-MMAE conjugate is designed with similar linker chemistry as ADC and PDC prepared by our customer using CellMosaic's Antibody MMAE Conjugation Kit （Cat#： CM11409） and Protein MMAE Conjugation Kit （Cat#： CM11413）.
It is synthesized at CellMosaic® for our customers' usage in horseradish peroxidase （HRP） based assay.
A long flexible PEG linker is also incorporated in the conjugate to retain the activity of HRP and MMAE binding.The final conjugate is purified to obtain a single MMAE-labeled HRP conjugate, and is lyophilized from PBS containing sugar-based stabilizer for easy shipping and storage.
The product is sold as 1 vial of 0.5 mg （Cat# CM53209-0.5MG） or 4 vials of 0.5 mg （Cat# CM53209-2MG）.
