特徴
- Hypoxia-Inducible Factor 1-Alpha (HIF-1-alpha or HIF1A) is an important mediator of the cellular and systemic responses to hypoxia, promoting survival and maintaining homeostasis in conditions of low oxygen. HIF1A regulates the expression of proteins such as erythropoietin, nitric oxide synthase, and mesenchymal-epidermal transition (MET) receptor, which promote angiogenesis, anaerobic metabolism, and many other survival pathways necessary in hypoxic environments. It has been suggested that tumour hypoxia and the resultant overexpression of MET by HIF1A promotes metastasis, and MET overexpression is correlated with poor prognosis and metastatic disease in the case of breast cancer. HIF-1α expression is associated with cancer progression and clinical outcome in many types of tumours, including breast cancer, type 1 endometrial carcinoma, sarcoma, head and neck tumours, and brain tumours.
仕様
- 容量:0.1ml
- フォーマット:Concentrate
- クローン:IHC601
- クラス:IgG
- 免疫動物:Rabbit
- Uniport:Q16665
- この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL:06-6447-8641
- FAX:06-6447-8642
- E-mail:[email protected]
商品のバリエーション (サイズ違い・スペック違い・オプション品など)
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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83-5603-88
HIF-1a 1ml
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83-5603-90
HIF-1a 7ml
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83-5603-89
HIF-1a 0.1ml
|
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掲載カタログ情報
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