概要：A2058 cells, derived from a lymph node metastasis of a 43-year-old male Caucasian patient with malignant melanoma, are highly invasive and valuable for studying cellular invasion.
They express proteins such as collagen type IV collagenase, tissue inhibitor of metalloproteinase-2 (TIMP-2), and autocrine motility factor.
They closely resemble the characteristics of the primary tumor, enhancing their relevance in melanoma research.
A2058 cells adhere well to culture surfaces, simplifying handling and providing a stable platform for experimentation.
They also exhibit high tumorigenicity when inoculated into mice, forming tumors within 21 days.
A2058 cells express nerve growth factor (NGF) and laminin receptors, allowing investigation of their roles in melanoma invasion and metastasis.
Understanding these interactions can provide insights into tumor progression and potential targeted therapies.
