概要：HeLa cells, derived from the cervical cancer cells of Henrietta Lacks, are an immortal cell line widely employed in biomedical research.
The human cell line Hela has significantly contributed to significant research advances and continues to play a pivotal role in laboratories worldwide.
In 1951, Henrietta Lacks, a young mother of five, sought medical attention at The Johns Hopkins Hospital for vaginal bleeding, where Dr.
Howard Jones identified a significant malignant tumor on her cervix.
At that time, the Johns Hopkins Medicine Institute was among the few institutions offering medical care to impoverished African Americans.
Henrietta Lacks underwent radium treatment for her cervical cancer, the leading therapy available then.
During her treatment, a biopsy was conducted, and a sample of her cancerous cells was sent to Dr.
George Otto Geys lab.
Dr.
Gey had been attempting to cultivate cells from cervical cancer patients of diverse backgrounds, but without success until Henriettas cells, which were the first cells to proliferate continuously, a discovery that set them apart from all previous samples.
Henrietta Lacks cervical carcinoma was later found to have been caused by the Human papillomavirus (HPV).
HPV is a common virus that can lead to cervical cancer among other diseases.
Research on HeLa cells has significantly contributed to understanding the role of HPV in cervical cancer, leading to the development of preventive HPV vaccines, which have had a profound impact on reducing the incidence of HPV-related cancers.
These extraordinary cells, termed 'HeLa' cells after Henrietta Lacks initials, have since become instrumental in medical research.
They have enabled scientists to investigate cancer cell growth, the impact of various substances, and the workings of viruses, significantly contributing to medical advancements, including the development of vaccines for polio and COVID-19, without the ethical concerns of direct human experimentation.
HeLa cells are widely used for gene function studies, recombinant protein production, and gene therapy due to their high transfection efficiency and susceptibility to viral infections.
They are pivotal in researching viral behaviors, including replication and pathogenesis, and have played a key role in Hepatitis B research by expressing viral proteins and aiding in the development of diagnostic tests and vaccines, thereby significantly advancing global health measures.
HeLa cells continue to be an invaluable resource for ongoing research in medicine and science.
The significance of HeLa cells and other immortal cell lines cannot be overstated, as they continue to shape the field of medicine and infectious disease research, and they represent a lasting legacy of Henrietta Lacks and her contributions to scientific advancement.
仕様
容量：1vial
カテゴリー：Reproductive system cancer cell lines
Organism：Human
Tissue：Cervix
Disease：Adenocarcinoma
Applications：Transfection host
Synonyms：HELA, Hela, He La, He-La, Henrietta Lacks cells, Helacyton gartleri
Age：30 years
Gender：Female
Ethnicity：African American
Morphology：Epithelial-like
Growth Properties：Adherent
Citation：HeLa (Cytion catalog number 300194)
Biosafety Level：1
Isoenzymes：G6PD, A
Virus Susceptibility：Human adenovirus 3, Encephalomyocarditis virus, Human poliovirus 1, Human poliovirus 2, Human poliovirus 3
Reverse Transcriptase：Negative
Products：Keratin, Lysophosphatidylcholine (lyso-PC) induces AP-1 activity and c-jun N-terminal kinase activity (JNK1) by a protein kinase C-independent pathway
Karyotype：The HeLa cell line, with its complex karyotype featuring a high degree of aneuploidy and structural rearrangements, is known for its rapid growth and longevity in culture. HeLa cells typically exhibit 82 chromosomes, although the range can vary from 70 to 164. Notably, 98% of HeLa cells possess a small telocentric chromosome, and 100% exhibit aneuploidy in a substantial number of cells examined. These chromosomal abnormalities underpin their fast growth and immortality, along with their association with cervical cancer and other cancerous cells.
