概要：Derived from the smooth muscle of the embryonic thoracic aorta in a BDIx rat, the A7r5 cell line offers a remarkable tool for studying cardiovascular diseases.
These fibroblast-like cells possess a unique flat ribbon-like morphology that differentiates into parallel arrays of spindle-shaped cells.
When the A7r5 cells enter the stationary phase of their growth cycle, there is a noticeable increase in myokinase and creatine phosphokinase (CPK) activity.
Furthermore, upon cessation of cell division, these cells synthesize a specific muscle type CPK isoenzyme.
This intriguing behaviour allows researchers to investigate the molecular mechanisms underlying cell differentiation and muscle development.
Researchers have employed the A7r5 cell line to investigate the impact of angiotensin II on vascular oxidative stress, shedding light on the role of this hormone in cardiovascular physiology.
Additionally, the cells have been utilized in a study focusing on the inhibitory effects of PLA2 (phospholipase A2) and its role in lipid droplet formation.
These applications highlight the versatility and relevance of the A7r5 cell line in elucidating critical pathways and potential therapeutic targets related to cardiovascular diseases.
仕様
容量：1vial
カテゴリー：Rat cell lines
Organism：Rat
Tissue：Aorta, thoracic, smooth muscle
Synonyms：A7R5
Breed：BDIx
Age：Embryo
Morphology：Fibroblast
Growth Properties：Adherent
Citation：A7r5 (Cytion catalog number 305198)
Biosafety Level：1
Protein Expression：Myokinase, Creatine Phosphokinase(Muscle Isoenzyme), Myosin
