概要:The 22Rv1 cell line is derived from a human prostate cancer xenograft that was propagated in mice after remission and relapse of the parental androgen-dependent CWR22.
Dihydroxytestosterone mildly affects these PSA-expressing cells.
They react positively to androgen receptor antibodies.
Epidermal-growth factor (EGF) stimulates growth, although transforming growth factor beta-1 does not (TGF beta-1).
Recent research has also shown that 22Rv1 cells produce large quantities of the human retrovirus xenotropic murine leukemia virus-related virus (xMRV).