概要：PC3 cells, established from the tissue of origin being bone metastasis in a 62-year-old Caucasian male with grade IV prostatic adenocarcinoma, are a cornerstone in the study of human prostate carcinoma.
The PC-3 human prostate cancer cell line is essential for the establishment and characterization of prostate cancers molecular and cellular underpinnings.
PC3 cells are widely used for studying the molecular and cellular aspects of prostate cancer, especially in the context of metastatic disease.
Their high metastatic potential makes them a valuable model for advanced prostate cancer research.
As epithelial cells, PC3s lack of response to androgens and their independence from typical growth factors like glucocorticoids or fibroblast growth factors, positions them uniquely among human prostate carcinoma cells for studying the impact of koenimbin and other potential therapeutic agents.
The absence of prostate-specific antigen (PSA) expression and low activities of testosterone-5-alpha reductase and acidic phosphatase set PC3 apart from other prostate cancer cell models like LNCaP and DU145, the former known for expressing luminal differentiation markers such as AR and PSA, and the latter representing a moderated metastatic potential of prostate carcinoma.
Furthermore, the role of the PC3 prostatic carcinoma cell line in prostate cancer stem cells research is underscored by the observation that a subset forms cancer stem cell holoclones, which exhibit high self-renewal, moderate drug resistance, and significant tumorigenicity under standard culture conditions.
This characteristic makes the PC3 cell line a critical model for studying the tumor environment, particularly through xenograft models where PC3 xenograft tumors are used to investigate tumor growth and response to therapies in vivo.
The distinction between the two sublines of PC3 cells, PC-3(AR-) and PC-3AR+, adds depth to prostate cancer research, providing avenues to explore the nuances of androgen receptor expression and its implications on prostate cancer progression and treatment.
仕様
容量：1vial
カテゴリー：Prostate cancer cell lines
Organism：Human
Tissue：Prostate
Disease：Adenocarcinoma
Metastatic Site：Bone
Applications：Transfection host
Synonyms：PC3, PC.3
Age：62 years
Gender：Male
Ethnicity：Caucasian
Morphology：Epithelial-like
Growth Properties：Adherent. The cells form clusters in soft agar and can be adapted to suspension growth
Citation：PC-3 (Cytion catalog number 300312)
Biosafety Level：1
Antigen Expression：HLA A1, A9
Tumorigenic：Yes, in nude mice
Karyotype：The karyotype of PC3 cells is notable for being triploid, containing multiple chromosomal abnormalities that contribute to their aggressive nature.
