83-5598-70　CDNR4 Cells 1vial　400391

特徴

• 概要：CDNR4 cells are a remarkable subset derived from the COMMA-D cell line, a mouse mammary carcinoma model.
• CDNR4 cells represent a clonal subpopulation of the COMMA-D cell line that has been extensively characterized for their unique properties and functions.
• Their similarity to mammary stem cells makes them a valuable tool for studying stem cell biology, carcinogenesis, and cell population heterogeneity.
• These cells were generated by transfection of a kanamycin and neomycin resistance transposon (Tn5 gene) and have since shown fascinating characteristics and properties.
• One of the most remarkable aspects of CDNR4 cells is their ability to functionally differentiate into preneoplastic and neoplastic phenotypes.
• The COMMA-D cell line from which they are derived was first characterized for heterogeneity using techniques such as phase contrast microscopy, immunocytochemical staining, DNA content analysis, and assessment of oncogenic potential.
• Clonal subpopulations of COMMA-D cells were isolated by transfection and selection procedures, and CDNR4 emerged as one of the notable clones.
• It is important to note that despite their clonal origin, these subpopulations often retained the heterogeneity observed in the COMMA-D parental lineage.