概要：The 4T1 cell line is a widely used model in cancer research due to its high similarity to human breast cancer.
Derived from a BALB/c mouse, the tumor growth and metastatic spread of 4T1 cells closely mimic the behavior of human breast cancer.
The 4T1 cell line is considered an animal model for stage IV human breast cancer, as it is able to spontaneously metastasize in both post-operative and non-surgical models.
This makes the 4T1-induced tumors a valuable tool for studying the progression and metastasis of breast cancer, as well as the efficacy of various treatments.
When injected into BALB/c mice, 4T1 cells spontaneously produce highly metastatic tumors that can spread to various organs such as the lung, liver, lymph nodes, and brain, while the primary tumor continues to grow in situ.
Furthermore, 4T1 cells are resistant to 6-thioguanine, which allows for the detection of micro-metastatic cells (as few as 1) with greater accuracy than most other tumor models.
This means that there is no need to count nodules or weigh target organs.
In addition, the 4T1 cell line has been used to study the molecular and cellular mechanisms underlying breast cancer progression and metastasis, including the role of signaling pathways, gene expression, and the tumor microenvironment.
Overall, the 4T1 cell line is a valuable tool for the study of breast cancer biology and the development of new treatments.
仕様
容量：1vial
カテゴリー：Mouse cell lines
Organism：Mouse
Tissue：Breast, mammary gland
Disease：Malignant neoplasm
Applications：4T1 cells accurately imitate the characteristics of human breast cancer in its most advanced stage - Stage IV.
