概要：B16 melanoma is a well-established and widely used cell line in cancer research, which was first established in 1954.
B16 cells are derived from the melanin-producing epithelia of C57BL/6 mice and are known for their ability to form metastases in the lung, liver, and spleen.
By utilizing B16 cells as a research model, researchers were able to gain a deeper understanding of the mechanisms by which cancer cells spread and establish themselves in various body organs.
B16 cells express very low amounts of the H-2Kb and H-2Db glycoproteins of mouse class I major histocompatibility complex.
Treatment with gamma interferon increases the expression of H-2 and the metastatic potential of B16 cells.
This discovery further advanced the understanding of the mechanisms of metastasis.
Current research with B16 cells focuses on the immune response of cells to vaccinations, the role of microRNA in modulating metastatic characteristics, and the use of B16 as a preclinical model for researching immunotherapy.
There are distinct sub-lines of B16 cells, each with its own particular properties.
B164A5 is the most aggressive melanoma cell line for the skin of C57BL/6J mice, followed by B16F10, B16-GMCSF, and B16FLT3.
The base medium for B16 cells is DMEM.
仕様
容量：1vial
カテゴリー：Mouse cell lines
Organism：Mouse
Tissue：Skin
Disease：Mouse melanoma
Synonyms：B-16, B16 melanoma, B16 subline B78, B78
Breed：C57BL/6
Gender：Male
Morphology：Mixture of spindle-shaped and epithelial-like cells
