概要：Derived from a fusion of Mus musculus B lymphocytes and myeloma cells, AE-1 hybridoma cells possess lymphoblast morphology and grow in suspension culture.
The derivation of AE-1 cells involves immunizing animals with purified human erythrocyte acetylcholinesterase, followed by fusion with Sp2/0-Ag14 myeloma cells.
AE-1 cells are specifically designed to target the antigenic determinant of human acetylcholinesterase.
They express immunoglobulin and a monoclonal antibody against this enzyme, providing researchers with a powerful tool to investigate the immunological aspects related to acetylcholinesterase in humans.
The isotype of AE-1 cells is IgG1, enhancing their binding affinity and functionality.
These cells offer remarkable antibody specificity, reacting with human and monkey acetylcholinesterase but binding to a different epitope compared to AE-2 cells.
This specificity enables precise targeting and evaluation of acetylcholinesterase-related processes in different species.
In the field of immunology, AE-1 cells find various applications.
Researchers can utilize them to study immune responses, antibody production, and antigen-antibody interactions.
These cells play a crucial role in advancing areas such as vaccine development, autoimmune disease research, and immunotherapy.
仕様
容量：1vial
カテゴリー：Mouse cell lines
Organism：Mouse
Tissue：Hybridoma
Applications：Immunology, production of therapeutic antibodies
Synonyms：AE1
Breed：BALB/c
Morphology：Lymphoblast
Cell Type：Hybridoma (Spleen, B cell)
Growth Properties：Suspension
Citation：AE-1 (Cytion catalog number 300635)
Biosafety Level：1
Protein Expression：Monoclonal antibody isotype: IgG1 against human ACHE (UniProtKB P22303)
