83-5598-10　Ba/F3 Cells 1vial　305224

特徴

• 概要：The BA/F3 cell line, derived from murine pro B cells, is pivotal in cancer research due to its IL-3 dependency and unique growth traits, including a mostly single, round cell morphology with some polymorphism.
• These cells, which express CD11b and F4/80 markers, are confirmed as Mus musculus through COI DNA barcoding and exhibit a near diploid murine karyotype with about 33% polyploidy.
• In the realm of targeted cancer therapies, BA/F3 cells are instrumental for evaluating kinase oncogenes and testing small-molecule kinase inhibitors, crucial for addressing cancer-associated kinome mutations.
• Their compatibility with high-throughput screening has made them a favored system for compound profiling and investigating drug resistance mechanisms, particularly those arising from mutations affecting inhibitor binding.
• Overall, BA/F3 cells are a critical resource in kinase drug discovery, aiding in the assessment of kinase mutations, drug efficacy, and resistance prediction, thereby accelerating the development of targeted cancer treatments.