Gazdar and associates in 1979 from the pleural fluid of a patient with small cell cancer of the lung.
The bone marrow specimen was taken prior to therapy.
仕様
容量：1vial
カテゴリー：Lung cancer cell lines
Organism：Human
Tissue：Lung
Disease：Small cell carcinoma
Metastatic Site：Bone marrow
Synonyms：H146, H-146, NCIH146
Age：59 years
Gender：Male
Ethnicity：Caucasian
Morphology：Epithelial-like
Growth Properties：Aggregates in suspension
Citation：NCI-H146 (Cytion catalog number 300182)
Biosafety Level：1
Receptors Expressed：insulin-like growth factor II receptor (IGF II)
Protein Expression：The cells stain positively for vimentin and keratin, but are negative for neurofilament triplet protein.
Antigen Expression：The line expresses elevated levels of four biochemical markers: neuron specific enolase, brain isoenzyme of creatine kinase, L-DOPA decarboxylase and bombesin-like immunoreactivity
Tumorigenic：Forms transplantable tumors in nude mice which histologically resemble tumor cells from the original biopsy specimen
Products：The cells produce relatively high amounts of c-myc mRNA, but c-myc DNA sequences are not amplified. The cells do not express vasopressin, oxytocin or gastrin releasing peptide.
Ploidy Status：Aneuploid
Msi Status：Stable (MSS)
Karyotype：This is a near triploid human cell line. The modal chromosome number is 68, but cells with 66, 70 and 71 chromosomes also occurred frequently. The x chromosomes were paired, and no Y chromosome was detected in QM stained preparations.
