概要：This line was established from lung cancer tissue obtained from a 59-year-old black male lung adenocarcinoma patient prior to therapy.
The cells carry the mutation of K-ras 12 and a mutation in the codon 246 (ATC ?ATG, isoleucine -|BiggerAs| methionine) of the p53 gene.
The cells express C-myc, L-myc, v-src, v-abl, v-erb B, c-raf 1, Ha-ras, Ki-ras and N-ras RNAs.
The cell line has a heterogeneous mRNA expression for PDGF A and B chain, transforming growth factor alpha and beta and the epidermal growth factor receptor (EGFR).
NCI-H23 exhibits a 20-fold higher level of c-myc DNA amplification without detectable c-myc RNA amplification.
The cells stain positive for keratins 5+8 and 18 and vimentin but negative for neurofilament.
The cells are L-dopa decarboxylase-negative.
The cells can form colonies in soft agarose with an efficiency of 9.7%.
仕様
容量：1vial
カテゴリー：Lung cancer cell lines
Organism：Human
Tissue：Lung
Disease：Lung adenocarcinoma
Synonyms：NCI-H23, NCI.H23, NCI H23 , H-23, NCIH23
Age：51 years
Gender：Male
Ethnicity：African
Morphology：Epithelial
Growth Properties：Adherent
Citation：H23 (Cytion catalog number 305044)
Biosafety Level：1
Protein Expression：myc+, src+, abl+, erb+, ras+, sis -
