概要：The H-MESO-1 cell line (Cytion catalog number 300186), is a human-derived cellular model originating from a Caucasian male afflicted with asbestos-induced pleural mesothelioma-an infrequent and aggressive malignancy predominantly affecting the pleural lining of the lungs.
An inherent and distinctive feature of the H-MESO-1 cell line is its tumorigenic potential.
This has been empirically demonstrated through the successful induction of tumor formation when these cells are engrafted into immunocompromised athymic nude mice.
The establishment of the H-MESO-1 cell line originally involved the xenotransplantation of primary tumor material obtained from Dr.
R.M.
Williams and Dr.
A.
Rossini.
Subsequent to this initial step, adaptation for in vivo transplantation was meticulously undertaken under the guidance of Dr.
A.E.
Bogden.
Furthermore, it is worth underscoring that this particular model recapitulates the clinical behavior of malignant mesothelioma in humans.
Consequently, it holds significant promise as an invaluable resource for the rigorous evaluation of novel therapeutic interventions, especially in the domains of chemotherapy and immunotherapy.
