特徴
- 概要：The 786-O cell line is a renal cell carcinoma cell line derived from a human renal papillary adenocarcinoma.
- These cells are commonly used in in-vitro research studies as a model for understanding the biology and behavior of renal cell carcinoma.
- The 786-O cell line is known to be highly invasive and has been used in studies investigating the effects of various drugs and treatments on renal cell carcinoma cells.
- These cells demonstrate both microvilli and desmosomes and have been successfully cultured in a soft agar medium.
- These cells also produce a peptide that is structurally similar to PTH (parathyroid hormone), which can be found in breast and lung tumors alike.
- This peptide possesses an N terminal sequence akin to the one of PTH, with comparable activity as well.
- its molecular weight amounts to 6000 daltons.
- Furthermore, the 786-O cell line has been used to study the molecular mechanisms involved in renal cell carcinoma progression, including angiogenesis and metastasis.
- Overall, the 786-O cell line has proven to be a valuable tool for advancing our understanding of renal cell carcinoma and developing new treatments for this disease.
仕様
- 容量：1vial
- カテゴリー：Kidney cancer cell lines
- Organism：Human
- Tissue：Kidney
- Disease：Renal cell carcinoma
- Applications：This cell line is an optimal choice for transfection.
- Synonyms：786-o, 786O, 786-0, 786.O, 786-O RCC, RCC 786-O, RCC_7860, RCC 7860, 7860, 786-0WT
- Age：58 years
- Gender：Male
- Ethnicity：Caucasian
- Morphology：Epithelial-like
- Growth Properties：Monolayer, adherent
- Citation：786-O (Cytion catalog number 300107)
- Biosafety Level：1
- Antigen Expression：CAIx +, as confirmed by FACS analysis.
- Tumorigenic：In immunosuppressed hamsters
- Products：The cells produce a PTH (parathyroid hormone) like peptide that is identical to peptides produced by breast and lung tumors. It has an N terminal sequence similar to PTH, has PTH like activity, and has a molecular weight of 6000 daltons.
- Ploidy Status：Hypertriploid. Y chromosome was observed in 60% of the cells analyzed.
- Karyotype：Hypertriploid. Y was present in 60% of cells examined
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