概要：A-498 cells are a valuable resource in cancer research, derived from kidney tissue obtained from a 52-year-old female kidney cancer patient in 1973.
These cells exhibit epithelial morphology, grow adherently and are suitable transfection hosts for cancer-related studies.
A-498 is classified as a 'classical' RCC cell line belonging to the NCI-60 panel and is widely used in cancer research.
While no mutations in the vhl gene have been detected in A-498, observations suggest a potential papillary origin based on histology and chromosomal analysis.
However, A-498 is generally considered a model for ccRCC, with some exceptions.
These human cells allow researchers to study various biological processes related to cancer.
Derived from Homo sapiens, specifically kidney tissue, A-498 cells are valuable for investigating kidney-specific mechanisms, signalling pathways, and potential therapeutic targets in renal cell carcinoma.
A-498 cells have tumorigenic properties, forming undifferentiated carcinoma tumours and demonstrating tumorigenicity in experimental models.
A-598 cells find applications in 3D cell culture, cancer research, high-throughput screening, and toxicology studies.
