83-5596-59　SW-480 Cells 1vial　300302

仕様

• 容量：1vial
• カテゴリー：Intestine cancer cell lines
• Organism：Human
• Tissue：Colon
• Disease：Adenocarcinoma, Grade IV, Dukes type B.
• Synonyms：SW480, SW 480, SW480E
• Age：51 years
• Gender：Male
• Ethnicity：Caucasian
• Morphology：Epithelial-like
• Growth Properties：Adherent
• Citation：SW-480 (Cytion catalog number 300302)
• Biosafety Level：1
• Receptors Expressed：Epidermal growth factor (EGF), keratin (immunoperoxidase staining). Matrilysin, a metalloproteinase associated with tumor invasiveness, is not expressed.
• Protein Expression：The cells express elevated levels of p53 protein.
• Antigen Expression：HLA A2, B8, B17, blood type A, Rh+. The line is negative for CSAp (CSAp-) and colon antigen 3
• Isoenzymes：G6PD, B, PGM1, 2, PGM3, 1, 6PGD, A, PEP-D, 1, ES-D, 1
• Tumorigenic：Yes, in nude mice
• Viruses：Reverse transcriptase negative
• Virus Susceptibility：Human immunodeficiency virus (HIV, LAV)
• Products：Carcinoembryonic antigen (CEA) 0.7 ng/106 cells/10 days, keratin, TGF-?. The cells have been reported to produce GM-CSF.
• Mutational Profile：SW-480 cells carry a homozygous Kras mutation in codon 12: GGT(Wt Gly) |BiggerAs|GTT(Val). There is a G-|BiggerAs|A mutation in codon 273 of the p53 gene resulting in an Arg-|BiggerAs|His substitution and a C-|BiggerAs|T mutation in codon 309 resulting in a Pro-|BiggerAs|Ser substitution.
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