83-5596-43　SW-620 Cells 1vial　300466

特徴

• 概要：SW-620 cell line has been isolated from the large intestine of a 51-year-old male individual with Dukes C colorectal cancer.
• This cell line is widely used in cancer and toxicology research due to its high tumorigenic and metastatic properties, forming solid sheets of tumor cells in vivo.
• The SW-620 cell line was derived from a metastatic lymph node in the same manner as the primary adenocarcinoma from which SW-480 was derived.
• The doubling time of SW-620 cells is around 20-26 hours.
• SW-620 cells have a rounded morphology with fewer protrusions and a less extended lamellipodial area.
• In contrast, SW-480 cells comprise an elongated (E-type) and a rounded (R-type) population, showing a large lamellipodial area with fine protrusions.
• The SW-620 cell line has a hyperdiploid karyotype, with a modal number of 50 and a range of 45 to 53.
• The stemline chromosome number is hyperdiploid, with several marker chromosomes common to S metaphases.
• The SW-620 cell line is highly tumorigenic in nude mice.
• SW-620 cells express c-myc, K-ras, H-ras, N-ras, Myb, sis, and fos oncogenes but have been found negative for CSAp and colon antigen 3.
• The cells produce only small quantities of carcinoembryonic antigen (CEA) and are positive for keratin by immunoperoxidase staining.
• The SW-620 cell line can be used as an in vitro model to study cellular processes known to be essential to metastasis and to assess cell growth with regards to the transforming growth factor-? (TGF-?) and heat shock protein 90 (Hsp90).
• Furthermore, this cell line has been utilized to study the relationship between zinc intake and the risk of colon cancer and to test for intrahepatic tumor cell growth after intraportal injection.