概要：The CAL-62 cell line, originally derived from the right lobe of the thyroid gland of a 70-year-old Caucasian woman in 1988, is particularly useful for investigating thyroid anaplastic carcinoma.
These human epithelial-like cells exhibit a distinctive monolayer growth pattern and possess notable tumorigenic properties.
When transplanted into immunodeficient nude mice, CAL-62 cells efficiently form tumors, providing researchers with a valuable in vivo model to explore the dynamics of tumor progression and assess potential therapeutic strategies.
Moreover, the rapid proliferation rate of CAL-62 cells, characterized by a doubling time of approximately 24 hours, offers a distinct advantage in time-sensitive experiments, significantly expediting discoveries in thyroid anaplastic carcinoma research.
Additionally, the characterization of CAL-62 cells includes specific genetic attributes, such as the presence of the KRAS p.G12R mutation and copy number changes at the 9p21.3 locus, reflecting the complex nature of thyroid anaplastic carcinoma.
The cell lines stable epithelial phenotype, coupled with its established radioresistance, underscores its relevance and importance in advancing our understanding of thyroid anaplastic carcinoma and potential therapeutic interventions.
仕様
容量：1vial
カテゴリー：Head-Neck cancer cell lines
Organism：Human
Tissue：Thyroid
Disease：Thyroid gland anaplastic carcinoma
Synonyms：Cal-62, CAL 62, Cal 62, CAL62, Centre Antoine Lacassagne-62
