概要：CAL 27 cells are well-established and widely recognized in oral squamous cell carcinoma (OSCC) research.
Isolated in 1982 from the tongue tissue of a 56-year-old Caucasian male, these epithelial cells have played a significant role in OSCC investigations.
Morphologically, CAL 27 cells exhibit a distinct epithelial growth pattern, adhering in a monolayer fashion, and are of polygonal shape with highly granular cytoplasm.
Immunocytochemical analysis confirms their epithelial origin through intense positive staining with anti-keratin antibodies.
These cells display sensitivity to specific chemotherapeutic drugs, such as VP16 (etoposide), CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea), VM26 (teniposide), ADM (adriamycin), CPA (cyclophosphamide), and MTx (methotrexate).
This sensitivity inhibits thymidine incorporation, a crucial step in DNA synthesis, making CAL 27 cells a valuable tool for assessing drug efficacy.
Conversely, CAL 27 cells exhibit resistance to certain treatments, including VDS (vindesine sulfate), CDP (cis-platinum), and ACTD (actinomycin D), shedding light on potential resistance mechanisms and the complexity of OSCC.
While CAL 27 cells have been exposed to mycoplasma infection, a 21-day BM Cycline treatment successfully eradicated the cell lines progeny.
They possess a doubling time of 45 hours, contributing to their unique characteristics in OSCC research.
仕様
容量：1vial
カテゴリー：Head-Neck cancer cell lines
Organism：Human
Tissue：Tongue
Disease：Tongue squamous cell carcinoma
Synonyms：Cal-27, CAL 27, Cal 27, CAL27, Cal27, Centre Antoine Lacassagne-27
