83-5595-54　AGS Cells 1vial　300408

特徴

• 概要：AGS cells were derived from an adenocarcinoma of the stomach of a 54-year-old Caucasian female who had not undergone any prior anti-cancer treatment.
• AGS cells have been found to have a knockdown NOD1 gene and exhibit NOD1-/cagPAI dependent expression of DEFB4.
• This characteristic makes them ideal for further investigations into the role of NOD1 in Helicobacter pylori-induced gastric tumors and potential therapeutic interventions.
• Moreover, the AGS cell line is known to carry persistent infection with parainfluenza virus type 5 (PIV5).
• This infection leads to altered expression patterns of virus proteins and, importantly, a significant reduction in STAT1 levels.
• PIV5 specifically targets STAT1, resulting in its proteasome-mediated degradation and blocking the interferon (IFN) response.
• In terms of growth properties, AGS cells are adherent, allowing for easy maintenance and manipulation in the laboratory setting.
• They were derived from tumor fragments resected from a patient who had not received any prior therapy, ensuring their suitability for investigating untreated gastric tumors.
• The karyotype of AGS cells reveals their hyperdiploid nature, with a modal chromosome number of 49 in approximately 60% of cells.
• Polyploidy is observed in about 3.6% of cells.
• Several distinct chromosomal aberrations are present, including der(8)t(1|8) (q12|p23), der(19)t(19|?) (q13.6|?), minute chromosome M3, and C-group-like M12.
• However, the origins of M3 and M12 remain unidentified.
• Additionally, the t(13q14q) rearrangement is observed in some cells.
• Notably, certain chromosomes, such as N20, X, N8, and N18, are present in single copy or show occasional variations, indicating some chromosomal heterogeneity in AGS cells.
• Furthermore, AGS cells possess tumorigenic potential, as evidenced by their ability to form tumors in athymic BALB/c mice.
• This characteristic opens up possibilities for in vivo studies and preclinical models.