概要：The IMR-90 cell line consists of fibroblasts harvested from the lung tissue of a 16-week-old female fetus, characterized by a normal, stable, diploid karyotype indicative of a typical human female.
Originated by W.W.
Nichols and colleagues, these cells are derived from a Caucasian background and exhibit fibroblast morphology, adhering to surfaces in culture.
Notably, IMR-90 cells have a finite lifespan in vitro, capable of undergoing up to 58 population doublings before reaching senescence, making them a valuable model for studying cellular aging and division limits.
IMR-90 serves as a viable alternative to the WI-38 cell line and other human lung fibroblast strains, especially when considering their division capabilities and viral susceptibilities.
This cell line is particularly advantageous for various applications in biological research, including 3D cell culture, where its robust growth and adherence properties facilitate the formation of complex tissue-like structures.
Moreover, its efficacy as a transfection host broadens its utility in genetic studies, allowing for the introduction and expression of foreign DNA.
Given its well-documented derivation, growth characteristics, and broad application spectrum, IMR-90 is instrumental in advancing research in cellular biology, genetics, and tissue engineering.
仕様
容量：1vial
カテゴリー：Fibroblasts
Organism：Human
Tissue：Fetal lung
Synonyms：IMR 90, IMR90, Institute for Medical Research-90, I90
