概要：The 6T-CEM cell line is a thioguanine-resistant variant of the CCRF-CEM human T-cell leukemia cell line.
These cells grow in suspension and are deficient in the enzyme hypoxanthine phosphoribosyl transferase (HPRT, HGPRT) which confers resistance to thioguanine.
In addition 6T-CEM are also known for secreting high levels of an immunosuppressive factor.
The 6T-CEM cells have been widely used as a fusion partner for creating human T-cell hybridomas.
Overall, 6T-CEM cells are a useful tool for researchers studying T-cell acute lymphoblastic leukemia, drug resistance, and the development of new treatment strategies and the molecular pathways involved in leukemogenesis, as well as for the generation of human T-cell hybridomas for immunological research.
